A baby with Down syndrome

Question NO 10

The risk of having a baby with Down syndrome for a 30-year-old
woman increases


a. If the father of the baby is age 40
b. If her pregnancy has been achieved by induction of ovulation by menotropins
(e.g., Follistin, Gonal F)
c. If she has had a previous baby with Turner syndrome (45,X)
d. If she has had a previous baby with triploidy
e. If she has had three first-trimester spontaneous abortions

Three consecutive spontaneous abortions

Question NO 9

A 26-year-old patient has had three consecutive spontaneous abortions
early in the second trimester. As part of an evaluation for this problem, the
least useful test would be


a. Hysterosalpinogram
b. Chromosomal analysis of the couple
c. Endometrial biopsy in the luteal phase
d. Postcoital test
e. Tests of thyroid function

A 24-year-old woman has had three first-trimester spontaneous abortions

Question NO 8

A 24-year-old woman has had three first-trimester spontaneous abortions.
Which of the following statements concerning chromosomal aberrations
in abortions is true?
a. 45,X is more prevalent in chromosomally abnormal term babies than in abortus
products
b. Approximately 20% of first-trimester spontaneous abortions have chromosomal
abnormalities
c. Trisomy 21 is the most common trisomy in abortuses
d. Despite the relatively high frequency of Down syndrome at term, most Down
fetuses abort spontaneously
e. Stillbirths have twice the incidence of chromosomal abnormalities as live births

Spontaneous loss in the first trimester

Question NO 7

After an initial pregnancy resulted in a spontaneous loss in the first
trimester, your patient is concerned about the possibility of this recurring.
An appropriate answer would be that the chance of recurrence


a. Depends on the genetic makeup of the prior abortus
b. Is no different than it was prior to the miscarriage
c. Is increased to approximately 50%
d. Is increased most likely to greater than 50%
e. Depends on the sex of the prior abortus